Reactivity of [(PNP)Mn(CO)₂] with Organophosphates

Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development methods for environmental remediation and passivation has been ongoing years. However, little progress made in therapeutic development exposure victims. Given the postexposure behavior OPA materials enzymes such as acetylcholinesterase (AChE), electrophilic therapeutics may be more beneficial than currently employed nucleophilic countermeasures. In this report, we present our studies an electrophilic, 16-electron manganese complex (iPrPNP)Mn(CO)2 (1) hydroxide derivative (iPrPNHP)Mn(CO)2(OH) (2). The reactivity 1 phosphorus acids 2 P–F bond diisopropylfluorophosphate (DIPF) were studied. role water both was investigated use 17O-labeled water. Promising results arising from reactions organophosphorus substrates reported.